Research
Aasland group
Functional annotation of proteins and protein domains
The majority of proteins have a modular architechture: they are composed of one or more globular domains and other more or less structured modules. Globular domains can often be associated with a particular molecular function. Therefore, functional annotation of individual proteins as well as whole proteomes relies, to a large extent, on prediction of globular domains and transfer of functional annotation by homology. read more
Jonassen group
Pattern discovery in molecular biology data
Our research is focused on development and application of computational methods and tools for the analysis of molecular biology data. Our emphasis is on methods for the discovery of recurring patterns and unexpected correlations that may be of biological significance. read more
Lenhard group
Bioinformatics of transcription and transcriptional gene regulation
Transcriptional regulation has been identified as the top-priority research subject of advanced post-genome bioinformatics.Binding site specificities of individual eukaryotic transcription factors are notoriously low, which precludes their application to genome-wide analysis. read more
Berezovsky group
Computational biophysics
Computational biophysics is currently at an exciting stage when rapid growth of genomic data is coupled with achievements in comprehensive coverage of individual protein structures, single-molecule experiments, and analysis of complex structures. read more
Reuter group
Molecular Modeling of Proteins Dynamics
To investigate the dynamical properties of proteins, we use a range of different molecular modeling tools such as molecular dynamics simulations and normal mode analysis. We use other techniques, such as hybrid QM/MM methods and homology modeling, aimed mainly at studying static properties. read more
Alumni
Liberles group
Evolutionary and phylogenetic approaches to comparative genomics
As species diverge, specific molecular changes drive phenotypic changes and ultimately adaptation. Understanding the mechanism of the evolution of new functionality in genomes and how this correlates with the phenotypic divergence of species is the central theme of my research group. read more